2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. MCHR1 (GPR24)

MCHR1 (GPR24)

Melanin concentrating hormone receptor 1

MCHR1 (GPR24)

Related Products

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MCHR1 (GPR24), also known as Melanin concentrating hormone receptor 1, is a class A G-protein-coupled receptor (GPCR). MCHR1 has received considerable attention, as potent and selective antagonists acting at that receptor display anxiolytic, antidepressant and/or anorectic properties. MCHR1 is the sole receptor expressed in rodents and couples to Gi and Gq proteins.

MCH is a ubiquitous vertebrate neuropeptide predominantly synthesized by neurons of the diencephalon that can act through two G protein-coupled receptors, called MCHR1 and MCHR2. MCHR1 can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.

MCHR1 (GPR24) Related Products (34):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1869
    Neuropeptide EI, rat
    		Antagonist
    Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.
    Neuropeptide EI, rat
  • HY-N2073S
    Ethyl linolenate-d5
    		Inhibitor
    Ethyl linolenate-d5 is the deuterium labeled Ethyl linolenate. Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC50 of 70 μM. Anti-melanogenesis Effects[1].
    Ethyl linolenate-d<sub>5</sub>
  • HY-136152
    MCHR1 antagonist 3
    		Antagonist
    MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. MCHR1 antagonist 3 is used to regulate energy metabolism.
    MCHR1 antagonist 3
  • HY-P1204A
    [Ala17]-MCH TFA
    		Agonist
    [Ala17]-MCH TFA, a MCH analogue (HY-P1525A), is a selective ligand for MCHR1 (Ki=0.16 nM) over MCHR2 (Ki=34 nM). [Eu3+ chelate-labeled [Ala17]-MCH shows high affnity for MCHR1 (Kd=0.37 nM) while has little demonstrable binding affnity for MCHR2.
    [Ala17]-MCH TFA
  • HY-100318
    NGD-4715
    		Antagonist
    NGD-4715 is a selective and orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist .
    NGD-4715
  • HY-P4745
    hMCH-1R antagonist 1
    		Antagonist
    hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an KB value of 3.6 nM. HMCH-1R antagonist 1 can bind to hMCHR1 and hMCHR2 with IC50 values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research.
    hMCH-1R antagonist 1
  • HY-107625
    SNAP 94847
    		Antagonist
    SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.
    SNAP 94847
  • HY-P1205
    MCH(human, mouse, rat)
    		Agonist
    MCH (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC50 values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively.
    MCH(human, mouse, rat)
  • HY-101699
    AMG-076 free base
    		Antagonist
    AMG-076 free base is an orally bioavailable and selective MCHR1 antagonist. AMG-076 free base results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice.
    AMG-076 free base
  • HY-101699A
    AMG-076
    		Antagonist
    AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice.
    AMG-076
  • HY-11085
    T-226296
    		Antagonist
    T-226296 is an oral active and selective melanin-concentrating hormone receptor antagonist with the IC50 values of 5.5 nM and 8.6 nM for human SLC-1 and rat SLC-1, respectively. T-226296 can be used for study of obesity and insulin resistance.
    T-226296
  • HY-107626
    ATC0065
    		Antagonist
    ATC0065 is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC50 of 15.7 nM for human MCHR1. ATC0065 does not exhibits significant activity for MCHR2. ATC0065 has anxiolytic and antidepressant activities.
    ATC0065
  • HY-100308
    SB-568849
    		Antagonist
    SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pKi of 7.7.
    SB-568849
  • HY-U00353
    MCHR1 antagonist 1
    		Antagonist
    MCHR1 antagonist 1 is a selective antagonist of melanin concentrating hormone-1 (MCH1) receptor, with a Kb of 1 nM and a Ki of 4 nM at human MCH1, and may be used to reduce the body mass.
    MCHR1 antagonist 1